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Grand Rapids, MI 49503

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TUBEROUS SCLEROSIS COMPLEX

Our lab has characterized the genomic landscape of TSC tumors using next-generation sequencing. We have gained a more comprehensive understanding of TSC tumor biology, and we are investigating whether novel, clinically actionable aberrations exist. TSC tumors are not always associated with second-hit somatic mutations to TSC1 or TSC2, suggesting that their pathogenesis may involve additional genetic events, which we are currently working to uncover.