Our lab has used predictive computational modeling and cell-based measurements to accurately model the autophagic process. We are now validating and extending our model to predict the therapeutic benefit of inhibiting autophagy in cancer. Additionally, our group conducts optimized kinase and phosphatase assays for in vitro evaluation of compounds identified in silico. Our research suggests that these kinase inhibitors modulate autophagy, and may be more selective and effective than current lysomotropic agents.


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